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EPO is erythropoietin (Erythropoietin) of the abbreviation. Human erythropoietin in the kidneys and liver by a hormone-like substances, can promote erythropoiesis. Taking erythropoietin, anemia, kidney disease can increase blood flow than the solubility of the patients (ie, increase the percentage of red blood cells in the blood). Since last year, the drug has entered the commercial market. Body hypoxia, increased production of this hormone and cause red blood cell proliferation. Doping is EPO erythropoietin according to the principle of synthetic, it can promote the generation of oxygen in the muscles, so that more muscle strength, work longer hours. Erythropoietin is the major mammalian regulating erythropoiesis regulatory factors. As a glycoprotein hormone EPO, can increase endurance athletes, mainly due to: the one hand, EPO stimulates bone marrow function, timely and effective manner to increase the number of red blood cells, thereby enhancing the oxygen carrying capacity of blood, even after use of 120 days can increase the hemoglobin, the hematocrit increased from 55% to 60% (generally only 37-49%). The other hand, EPO can enhance the body's oxygen binding, transport and supply capacity, conducive to high-intensity sports, the improvement of hypoxia, and promote muscle oxygen species, so that the muscles more powerful, longer working hours. Especially for this in cycling endurance athletes, the skeletal muscle fiber types in a larger proportion of slow-twitch fibers in skeletal muscle is primarily rely on aerobic methods of energy supply, oxygen supply ability to directly affect the efficiency of skeletal muscle so if you use EPO to increase the efficiency of skeletal muscle, the effect is obvious.
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Erythropoietin (EPO): A hormone produced by the kidney that promotes the formation of red blood cells in the bone marrow. EPO is a glycoprotein (a protein with a sugar attached to it). Human EPO has a molecular weight of 34,000.
The kidney cells that make EPO are specialized and are sensitive to low oxygen levels in the blood. These cells release EPO when the oxygen level is low in the kidney. EPO then stimulates the bone marrow to produce more red cells and thereby increase the oxygen-carrying capacity of the blood.
EPO is the prime regulator of red blood cell production. Its major functions are to promote the differentiation and development of red blood cells and to initiate the production of hemoglobin, the molecule within red cells that transports oxygen.
The EPO gene has been found on human chromosome 7 (in band 7q21). EPO is produced not only in the kidney but also, to a lesser extent, in the liver. Different DNA sequences flanking the EPO gene act to control kidney versus liver production of EPO.
The measurement of EPO in the blood is useful in the study of bone marrow disorders and kidney disease. Normal levels of EPO are 0 to 19 mU/ml (milliunits per milliliter). Elevated levels of EPO can be seen in polycythemia, a disorder in which there is an excess of red blood cells. Lower than normal levels of EPO are seen in chronic renal failure.
Using recombinant DNA technology, EPO has been synthetically produced for use in persons with certain types of anemia -- such as anemia due to kidney failure, anemia secondary to AZT treatment of AIDS , and anemia associated with cancer.
This product was added to our catalog on Tuesday 09 August, 2011.
